Mohammadreza Guiti, MD; Arash Sherafat Vaziri, MD; Leila Oryadi Zanjani, MD; Amirreza Farhoud, MD
Abstract
Background: The aim of this study was to assess the isokinetic measures of surgically repaired ruptures of the pectoralis major muscle in contrast to non-injured side of the patients and specify the most affected movement of the injured side.Methods: Nine pectoralis major muscle tears in nine patients ...
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Background: The aim of this study was to assess the isokinetic measures of surgically repaired ruptures of the pectoralis major muscle in contrast to non-injured side of the patients and specify the most affected movement of the injured side.Methods: Nine pectoralis major muscle tears in nine patients were studied.They were all operated by the same surgeon and after 2.4 years (1-4 years) of follow up they were clinically examined. They completed a standard questionair and isokinetic dynamometry were carried out bilaterally. There was also a group of six non-injured bodybuilders who were assessed by isokinetic dynamometry to give us normal differences in the values of both limbs.Results: In the patient group, the mean torque of flexion was not different between the injured and uninjured sides (p < /em>≥.05). For the extension movements, the difference was significant (p < /em>
Reza Erfanian Reza; Masoumeh Firouzi, PhD; Mohammad Hossein Nabian, MD; Masoud Darvishzadeh, PhD; Leila Oriadi Zanjani, MD; Shayan Abdollahzadegan; Reza Shahryar Kamrani, MD
Abstract
Background: The use of fibrin adhesive has broad background in medicine and peripheral nerve repair. The physical properties of these adhesives has restricted their usage. This experiment studied the performance and physical characteristics of fibrin glue (which is prepared from single donor human plasma) ...
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Background: The use of fibrin adhesive has broad background in medicine and peripheral nerve repair. The physical properties of these adhesives has restricted their usage. This experiment studied the performance and physical characteristics of fibrin glue (which is prepared from single donor human plasma) in the repair of posterior tibial nerve of rat.Methods: In this study, posterior tibial nerves of 40 rats were transected. In group A no repair was performed in group B repair was done by one microsuture in group C repair was done by three microsutures in group D by one suture plus fibrin adhesive and in group E repair was done just with fibrin adhesive. After 8 weeks of follow-up, Tibial Function Index and at the end of the study, adhesive strength inflammation and scar formation were measured.Results: Functional recovery in the eighth week for groups A and E were significantly lower than groups B and C (p < /em>=.03). No rat repaired with fibrin adhesive had dehiscence, while half of rats in group A had complete dehiscence- was significantly higher than the others groups (p < /em>=.002). Inflammation and scar tissue were similar between the groups.Conclusion: The produced fibrin adhesive provides required adhesive and could hold nerve stumps in long term.
Reza Shahryar Kamrani, MD; Masoumeh Firuzi; Mohammad Hosein Nabian; Leila Oriadi Zanjani; Mostafa Shaahrezaee, MD
Abstract
Background: The treatment of large peripheral nerve defect in scarred tissue is still a major challenge. Two-stage grafting with preparation of a smooth bed before grafting is a technique used for tendon or bone defects in the past. We are now reporting such a technique for large scarred gaps in the ...
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Background: The treatment of large peripheral nerve defect in scarred tissue is still a major challenge. Two-stage grafting with preparation of a smooth bed before grafting is a technique used for tendon or bone defects in the past. We are now reporting such a technique for large scarred gaps in the sciatic nerves of rat.Methods: In each of the 20 female Wister rats, 15 centimeters of the sciatic nerve was excised. The nerve bed was then covered by tetracycline powder to induce scar tissue formation. In half of the rats a silicone tube was sutured into the nerve ends to produce a smooth tunnel for a two-stage grafting. In the second group the cut nerve ends were covered by silicone caps. After 4 weeks each rat received nerve grafting of its sciatic nerve defect from its bilateral median nerves. 15 weeks following the grafting the rats were tested for their sciatic nerve functions, then the nerves were excised for histological evaluation of the nerve regeneration and the scar tissue.Results: The motor and sensory motor function recovery of the nerves, as measured by “External Postural Thrust”, and “Withdrawal Reflex Latency”, were greater in the group that had the grafts replacing the silicone tubes. The histological evaluation also confirmed the presence of more nerve fibers and less scarring in the silicone tube treated group.Conclusions: Two-stage nerve grafting in severely scarred bed can improve the functional results of a nerve graft.
